Known Diablo 3 skill runes:

• Multistrike: Hits multiple targets (Hydra rune)
• Power:  adds some damage to the target (Force rune)
• Striking: adds an effects such as stun, knockback etc. to the target (Striking rune)
• Lethality: adds some effects or power when target is killed (Viper rune)
• Energy: alter or adds energy (Energy rune) 

Runes have different quality level (which set the power of the rune)

How runes can be used with the Diablo 3 skills system:

• Active skills have one socket for runes
• Passive skills have no sockets sockets
• Each skill have one socket for runes

(Click to enlarge the picture)

List of known Diablo III Rune / Skill Combinations: 

Barbarian Rune Skills: 

• Juggernaut Skills 
  • Bash 
    • Multistrike – multiple attacks, a la Zeal (Mattyman174) 
    • Power – focused, uninteruptable attack with large defense bonus, a la Concentration 
    • Striking – wild, devastating attack, with huge damage but zero defense, a la Berserk (keeping the magic damage is also probably a good idea)
  • Cleave 
    • Multistrike - 
      • hits extra targets (Peaceonearth) 
      • swings repeatedly in one use (a la Zeal) (Dark_blood3)
    • Power – adds 30% Crushing Blow (Peaceonearth)
  • Ground Stomp 
    • Power – the stomp releases (some kind of elemental energy) which lingers in the area of the stomp, damaging things (Ukobach)
  • Revenge 
  • Taunt 
  • Seismic Slam 
    • Multistrike – shockwave is wider and goes farther (Dark_blood3) 
    • Striking – adds knockback effect (allowing you to push a monster back to be hit by the wave again and again) (Dark_blood3)
• Battlemaster Skills 
  • Battle Rage 
  • Hammer of the Ancients 
    • Multistrike – hits behind the Barbarian before swinging forward to hit in front of him. Higher level runes hit back and forth repeatedly (Ukobach)
  • Battle Cry 
    • Striking – War Cry (Chanceford3)
  • Furious Charge 
    • Striking – the speed of the Barbarian’s charge forces the air (s)he moves through to move violently, damaging enemies near the path of the charge (Ukobach)
  • Ignore Pain
• Berserker Skills 
  • Frenzy 
    • Striking – extra Fury gain from hitting enemies (Peaceonearth)
  • Terrifying Shout 
    • Power – panic spreads among the Barbarian’s enemies; every fleeing monster who reaches another monster triggers them to flee as well
  • Onslaught 
  • Leap Attack 
    • Multistrike - 
      • “bunny hopping” – allow repeated short jumps to continuously keep moving and make it harder for enemies to target the Barbarian while he attacks (Elitemantis) 
      • larger AoE on landing (Dark_blood3)
  • Enrage 
  • Whirlwind 
    • Multistrike - 
      • Barbarian’s whirling motion causes counter-whirling twisters to form on the edge of the whirlwind, which eventually break off and move randomly away from the Barbarian (Kintak) (Bstapylton) 
      • damages multiple enemies in range per hit-check (Dark_blood3)
    • Striking – larger radius of damage around the Barbarian (Dark_blood3) 
    • Power – the whirlwind is so powerful as to suck nearby enemies into it (Drdoom)

Witch Doctor Rune Skills: 

• Skull of Flames 
  • Lethality – enemies killed remain for a little while as flame-enshrouded spirits which fight for the Witch Doctor
  • Multistrike – bounces, hiting things repeatedly 
  • Power – leaves a pool of flame on the ground where it hits
• Horrify 
  • Power – instead of running away, enemies are rooted in place by the fear, completely unable to move
• Locust Swarm 
  • Multistrike – Releases multiple (depending on strength of the rune) swarms in different directions; the swarms stack so that if they spread to the same group the group takes double (or more) damage (Ukobach, modified by myself) 
  • Lethality - 
    • when the swarm kills an enemy, a portion of takes its place as a “locust man”, which lasts for a brief time and does melee damage (Ukobach) 
    • enemies killed by the swarm explode, damaging nearby monsters (Akaitsuki)
• Mass Confusion 
  • Striking – can target a single enemy, who will be designated as the target of all other enemies in range 
  • Power – all confused monsters get 100% damage boost (Akaitsuki)
• Soul Harvest 
  • Multistrike – Soul Harvest becomes a passive Aura, which gradually drains Life from nearby monsters and converts it to Mana for the Witch Doctor (Sied2) 
  • Striking – attack summon a la Bone Spirit (Sied2) 
  • Lethality - 
    • enemies killed with Soul Harvest heal not only the Witch Doctor as normal, but also all allies (Sied2) 
    • enemies killed by Soul Harvest have a chance of completely restoring the Witch Doctor’s health and mana
• Summon Mongrel 
  • Striking – Mongrels have a higher chance of Critical Hit (Peaceonearth) 
  • Lethality – Mongrels explode much more violently, dealing their enchanted damage as well as improved normal explosion damage (Peaceonearth) 
  • Power – Mongrel attacks get Knockback and Stun (Peaceonearth) 
  • Multistrike - 
    • summons more Mongrels (Peaceonearth) (in another thread, Keighvin) 
    • summons Cerberus-like multi-headed Mongrels (in another thread, Keighvin)
• Wall of Zombies 
  • Multistrike – Zombie Prison (Mattyman174) 
  • Power - 
    • zombies leech health from enemies, which is transferred to the Witch Doctor (Kintak) 
    • summons unrooted Zombies – Army of Zombies! (Craigbeme)
  • Lethality - 
    • Enemies killed by Zombie Wall turn into Zombified versions of themselves, which then attack their former comrades (Kintak) 
    • Zombies from the wall that die leave behind a pool of acid (Mattyman174)
• Firebats 
• Plague of Toads 
  • Lethality – instead of a large number of small toads, summons a single big toad which can swallow small enemies whole. After eating a certain number, it explodes for poison splash damage (Ukobach)
• Spider Statue

• • Mirror Image 

Wizard Rune Skills: 

• Arcane Spells 
  • Magic Missile 
    • Multistrike – missiles get Pierce (Peaceonearth)
  • Disintegrate 
    • Multistrike – reflect off of walls, allowing the beam to be bounced around corners or to hit the same target repeatedly (not mine; forget whose idea this was) 
    • Striking – target gives off heat, dealing some fraction of the damage it takes to nearby enemies
  • Wave of Force 
    • Striking – pulls enemies towards Wizard and microstuns them 
    • Power – pushes enemies as far as they can go – taking extra damage if they hit a wall, damaging other monsters they hit, etc 
    • Lethality – after pushing the target, if it dies, it explodes with a wave of force of its own, allowing chain reactions
  • Arcane Orb 
    • Multistrike – launches Magic Missiles around it in circles – unFrozen Orb! 
    • Power – on a critical hit, leaves behind a small Slow Time bubble
  • Electrocute 
    • Multistrike – becomes Chain Lightning 
    • Lethality – enemies killed with Electrocute explode, dealing shock damage to nearby enemies
  • Slow Time 
    • Power(?) - 
      • instead of slowing time down, increases the speed of time massively, causing enemies within the bubble to age (permanent degradation to movement speed, attack speed, defense, attack rating, damage, max health). If max health goes to 0 within the bubble, the enemy crumbles to dust. (Ukobach) 
      • larger bubble (Telzents)
    • Lethality - 
      • Each second within the bubble, enemies within take the sum total of all damage taken so far within the bubble again, a la DotA’s Maledict (compound damage!) 
      • enemy killed within bubble explodes (Telzents)
    • Striking - 
      • all projectiles that strike the bubble damage everything inside of it evenly for a percentage of the original damage (based on rune quality) 
      • everything within bubble when it is first placed takes damage (Telzents)
    • Multistrike - 
      • increases the movement and attack speeds of all allies in the bubble, increasing how often they’re attacking targets within (Asmo45) 
      • multiple bubbles (?) (Telzents)
  • Temporal Armor 
    • Striking - 
      • after absorbing damage, it deals a percentage of the damage to all targets within an area of effect. At highest rune levels, the percentage would be greater than 100%. (Peaceonearth) 
      • enemies who strike the armored Wizard are temporarily time-stopped (Schpwuette)
    • Power – costs less Mana (Peaceonearth) 
    • Multistrike – lowers the cooldown between damage absorption events (Peaceonearth)
  • Teleport 
    • Power – can be cast on self, allies, or enemies. Semi-teleports the target, leaving them temporarily half real. In this they take and deal extra magic damage, cannot use physical attacks, and take less physical damage (Kintak) 
    • Wizard can teleport into a minor monster, killing them in a violent explosion (Ukobach)
    • Multistrike – appear at destination with a mirror image 
    • Striking – damage enemies near destination
• Storm Spells 
  • Charged Bolt 
    • Multistrike - 
      • monsters hit with bolts release bolts of their own (a la Lightning Enchanted monsters) to damage other targets 
      • bolts get Pierce (Telzents)
    • Striking - 
      • instead of charged bolts, Wizard instead releases the same number of lightning bolts which hit the nearest N targets, a la Forked Lightning in WC3 
      • bolts are homing (Telzents)
    • Power – struck enemies glow and deal a fraction of the damage taken to nearby enemies (Telzents) 
    • Energy – bolts travel faster (Telzents) 
    • Lethality – enemies killed with Charged Bolt release bolts of their own (a la Lightning Enchanted monsters) to damage other targets (Telzents)
  • Frost Nova 
    • Multistrike – struck enemies release their own Frost Novas. At higher levels, enemies hit by those novas also release novas, and so on.
  • Storm Armor 
  • Ray of Frost 
    • Multistrike – splits on striking, a la Lightning Fury 
    • Power – slowly degrades target’s movement and attack speed as the spell is focused on them; damage is healed slowly over time after spell stops 
    • Lethality – on death, target releases Frozen Orb-esque explosion of Frost Bolts
  • Tornado 
    • Multistrike – tornado spins faster, dealing its damage more rapidly (i.e. shorter NextDelay, in D2 terms) 
    • Power – lifts the target(s) and pulls them along with it until it dissipates 
    • Lethality – powerful centrifugal forces literally tear the target apart, violently – Corpse Explosion
  • Blizzard 
    • Multistrike - 
      • adds a swirling vortex to Blizzard, pulling nearby enemies into it and keeping enemies in it underneath the storm 
      • expanded area of effect – boring, but powerful
    • Striking – Blizzard is centered over the Wizard and moves with him/her
• Conjuring Spells 
  • Spectral Blade 
    • Multistrike – hits all enemies around the Wizard 
    • Striking – small increase in the range of Spectral Blade
  • Stone Skin 
    • Power – lengthens duration of armor (Peaceonearth) 
    • Multistrike – Creates “layers” of armor, which break independently and can be recast independently as well, so that recasts are cheaper (Peaceonearth)
  • Mirror Image
  • Multistrike – extra images 
  • Striking – images do extra damage
  • Meteor Storm 
    • Multistrike – meteors fall more quickly (over the same period of time) 
    • Power – storm lasts half as long, but ends with a single huge meteor for massive damage
  • Acid Cloud 
    • Power – degrades attack damage and defense of enemies as they stay within the cloud 
    • Lethality – for every enemy who dies within the cloud, the damage dealt to those within the cloud increases
  • Hydra 
    • Multistrike - 
      • Hydra breathes arc-shaped fan of fire 
      • Hydra shoots Fireballs instead of Fire Bolts
    • Power – Hydra breathes continuous stream of fire, a la Inferno 
    • Striking – summons an entire Hydra, instead of just the head, making the beast mobile
  • Magic Weapon 
    • Multistrike – imbues the weapons of all party members with the magic damage 
    • Lethality – for every enemy killed with the imbued blade, the damage bonus increases until the effect wears off 
    • Striking? – instead of imbuing a weapon with magic damage, instead conjures a floating scimitar a la the ones in trapped Chests and Urns in Act II. Higher rune quality means more swords lasting longer (Ukobach)

Thanks to many supporters of the Diablo 3 community for this list of known Diablo 3 rune & skills combinations.. If you have any comments please feel free to post.